Author

Xuelin Lou

Medical College of WisconsinORCID 0000-0002-0576-8575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Prince Joshi· 2 shared Fan FaniD· 1 shared Fan FaniD· 1 shared Michael Abayomi AbiolaiD· 1 shared Q. Liu· 1 shared Sandeep Kumar KotturuiD· 1 shared Xiaojie LiuiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Prince Joshi

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2 papers

Recent·Most cited

Parkinsonism Reversal and Dopaminergic Resilience: Lessons from a Rotenone-induced Parkinson's Disease Model

Prince Joshi, Fan Fan, Xuelin Lou

This study shows that rotenone-induced Parkinsonism in mice is reversible, with full recovery of motor and non-motor deficits and dopaminergic neuron density after 12 months.

bioRxiv · Dec 23, 2025 · PreprintNeuroscience

NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer's disease

Fan Fan, Prince Joshi, Xiaojie Liu, Sandeep Kumar Kotturu, Michael Abayomi Abiola, Q. Liu, Xuelin Lou

This paper identifies Sarm1 as a driver of synapse degeneration and memory loss in Alzheimer's disease by showing its deletion prevents synapse loss and cognitive decline in mouse models.

bioRxiv · Dec 23, 2025 · PreprintNeuroscience