Fan Fan

This paper provides a detailed protocol for isolating and cannulating the rat middle cerebral artery for pressure myography across diverse genetic models.

This study shows that inhibiting soluble epoxide hydrolase with TPPU improves cognitive function in diabetic-related dementia by enhancing cerebral blood flow and reducing neuroinflammation and gliosis.

This paper identifies Sarm1 as a driver of synapse degeneration and memory loss in Alzheimer's disease by showing its deletion prevents synapse loss and cognitive decline in mouse models.

This study shows that dual inhibition of sEH and COX-2 with PTUPB improves cognition in AD rats by enhancing myogenic response and cerebral artery distensibility.

This study shows that inhibiting soluble epoxide hydrolase (sEH) with TPPU improves cerebral blood flow autoregulation and cognition in Alzheimer's and diabetes-related dementia rat models.

This paper identifies NaviPA1, a peptide that inhibits specific sodium channels in sensory neurons, reducing neuropathic pain in rats and human-derived neurons.

This study examines the structural and mechanical properties of the middle cerebral artery in Dusp5 KO rats, finding limited structural changes but enhanced myogenic tone, suggesting Dusp5's role in hemodynamics and cognition is enzyme-driven.

The paper longitudinally studies cerebral hemodynamics in TgF344-AD rats, finding impaired vascular responses and autoregulation before cognitive decline.

The paper identifies Piezo2 expression in neuronal and non-neuronal cells of the rat peripheral sensory pathway and links its elevation to pain conditions.