Kathryn N. Ivey

This study demonstrates the use of in vivo prime editing to correct a cardiomyopathy-causing mutation in a humanized mouse model, rescuing disease phenotypes.

This study demonstrates that AAV gene therapy with TN-201 restores MYBPC3 protein levels, reverses cardiac hypertrophy, and improves survival in a murine model of MYBPC3-associated HCM.

This study identifies metabolic defects in PKP2-deficient cardiomyocytes and shows that restoring PKP2 improves contractility and electrophysiological properties.

This study investigates how Gata4, Mef2c, and Tbx5 drive cardiac reprogramming by analyzing transcriptomic and epigenomic changes in fibroblasts.

The paper shows that a congenital heart defect can result from three inherited heterozygous missense variants in MYH7, MKL2, and NKX2-5.