BioengineeringACS Central SciencePeer-reviewed
An antifungal with a novel mechanism of action discovered via resistance gene-guided genome mining
Bruno Perlatti, Sandeep Vellanki, Yalong Zhang…·Colin J. B. Harvey
This study identifies a novel antifungal compound targeting ALS, validated through genome mining, biochemical assays, and a mouse model of invasive aspergillosis.
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