Colin J. B. Harvey

geneML improves fungal gene prediction accuracy and recall using deep learning, outperforming existing tools and enabling faster, more comprehensive genome annotation.

This study identifies a novel antifungal compound targeting ALS, validated through genome mining, biochemical assays, and a mouse model of invasive aspergillosis.

The paper develops a biosensor to study PDR regulation in yeast, identifying novel regulators and linking PDR to cell cycle control.

A yeast-based refactoring platform (HEx) with new inducible promoters, an engineered host strain, and homology-based assembly expressed 41 cryptic fungal gene clusters; 22 yielded non-native compounds.