Tina Fink

Pharmacologically regulated bioorthogonal stabilization domain for regulation of CAR T cells

This paper develops a pharmacologically controlled system for regulating CAR T cell function using estrogen receptor-based degron domains and FDA-approved compounds.

Designed allosteric protein logic

The paper introduces a system to regulate protein function and create Boolean logic gates using coiled-coil dimers in protein loops, demonstrated on ten diverse proteins.

Regulation of protein secretion through chemical regulation of endoplasmic reticulum retention signal cleavage

The paper introduces two genetically encoded secretion systems that enable fast, chemically regulated protein secretion by cleaving ER retention signals, bypassing the need for transcription and translation.