Author

Ashutosh Tripathy

University of North Carolina at Chapel HillORCID 0000-0001-9922-735XUnclaimed ORCID profile · follow to get notified of new preprints

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Ashutosh Tripathy1 paper · Justus-Liebig-Universität Gießen

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Synthetic Biology· 1

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1

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Brian A. KuhlmaniD· 1 shared John SondekiD· 1 shared Matthew C. CumminsiD· 1 shared

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2023-2023 · peak 1/yr

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Brian A. KuhlmanORCID

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Synthetic BiologybioRxivPreprintMar 28, 2023

De novo design of stable proteins that efficaciously inhibit oncogenic G proteins

Matthew C. Cummins, Ashutosh Tripathy, John Sondek, Brian A. Kuhlman

The paper designs de novo proteins that inhibit oncogenic Gq by embedding binding motifs, achieving high stability and potency without further optimization.

DOI 10.1101/2023.03.28.534629

humanprotein structure

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