John Sondek

PHENOMS: Open-Source Software for Rust-Accelerated Hydrogen-Bond Analysis in Molecular Dynamics Simulations

PHENOMS analyzes hydrogen-bond networks in molecular dynamics simulations using Rust-accelerated code, achieving significant speedup over Python-based tools and demonstrating its utility with HDX-MS data.

Optogenetic control of PLC-γ1 activity directs cell motility

This study shows that local activation of PLC-γ1 via optogenetic tools can direct cell motility, revealing its role in chemotaxis beyond mere signaling.

Hyperactive PLCG1 drives non-canonical signaling to promote cell survival

This study identifies hyperactive PLCG1 mutations in T-cell leukemia/lymphoma that drive non-canonical signaling, enhancing cell survival and drug resistance.

Genetic Variants of Phospholipase C-γ 2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimers Disease

The paper identifies a PLCG2 variant, PLCG2M28L, associated with increased Alzheimer's disease risk and altered microglial phenotypes, while another variant, PLCG2P522R, reduces disease risk in a mouse model.

De novo design of stable proteins that efficaciously inhibit oncogenic G proteins

The paper designs de novo proteins that inhibit oncogenic Gq by embedding binding motifs, achieving high stability and potency without further optimization.

PLCG2 as a Risk Factor for Alzheimer's Disease

The paper identifies a rare PLCG2 variant that increases Alzheimer's disease risk and shows increased PLCG2 expression correlates with amyloid deposition in AD patients.