PhysiologybioRxivPreprint
Thin Filament Interaction and Ca2+-Desensitization Effect of the C-Terminal End Peptide of Cardiac Troponin T Where Loss of Function Mutations Cause Hypertrophic Cardiomyopathy
Qiaobin Li, Han‐Zhong Feng, Jian‐Ping Jin
This study investigates the function of the C-terminal end peptide of cardiac troponin T and shows that HCM mutations impair its Ca2+-desensitization effect, suggesting it as a potential drug target for heart failure.
DOI 10.1101/2025.07.05.663331