Author

Elida M. Gomero

St. Jude Children's Research HospitalORCID 0000-0001-9980-9042Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2

Frequent Co-Authors

Alessandra d’AzzoiD· 3 shared Diantha van de VlekkertiD· 3 shared Jason A. WeesneriD· 3 shared Leigh E. FremuthiD· 3 shared Ida AnnunziataiD· 2 shared Yvan CamposiD· 2 shared Ashutosh MishraiD· 1 shared Camenzind G. RobinsoniD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Alessandra d’AzzoORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

AAV-mediated gene therapy for Sialidosis

Diantha van de Vlekkert, Huimin Hu, Jason A. Weesner, Leigh E. Fremuth, Scott A. Brown, Meifen Lu, Elida M. Gomero, Yvan Campos, Heather Sheppard, Alessandra d’Azzo

This study tests AAV-mediated gene therapy for sialidosis in a mouse model, showing restored NEU1 activity and reduced tissue damage.

Molecular Therapy · May 25, 2024Peer-reviewedGenetics

Neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of Trem2

Leigh E. Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason A. Weesner, Elida M. Gomero, Alessandra d’Azzo

This study shows that Neu1 regulates microglial function by modulating Trem2 sialylation, affecting phagocytosis and cytokine production.

bioRxiv · May 20, 2024 · PreprintNeuroscience

Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spineformation

Jason A. Weesner, Ida Annunziata, Diantha van de Vlekkert, Camenzind G. Robinson, Yvan Campos, Ashutosh Mishra, Leigh E. Fremuth, Elida M. Gomero, Huimin Hu, Alessandra d’Azzo

This study shows that altered GM1 catabolism disrupts ER-PM junctions, increases Ca2+ signaling, and promotes synaptic spine formation in a neurodegenerative disease model.

bioRxiv · Jul 10, 2023 · PreprintNeuroscience