Leigh E. Fremuth

This study shows that microglia reduce seizure severity through P2RY12 signaling, as demonstrated in genetic models and seizure paradigms.

This study identifies Neu1 and PPCA as regulators of APP metabolism in Alzheimer's disease, showing their therapeutic potential in reducing amyloid pathology.

This study tests AAV-mediated gene therapy for sialidosis in a mouse model, showing restored NEU1 activity and reduced tissue damage.

This study shows that Neu1 regulates microglial function by modulating Trem2 sialylation, affecting phagocytosis and cytokine production.

This study shows that altered GM1 catabolism disrupts ER-PM junctions, increases Ca2+ signaling, and promotes synaptic spine formation in a neurodegenerative disease model.