Genome-wide extraction of differentially methylated DNA regions using adapter-anchored proximity primers
Farzaneh Darbeheshti, Hayet Radia Zeggar, Hamzeh Salmani, Yibin Liu, Eleni Thanou, Athina N. Markou, Giannis Vatsellas, Samira Ghazali, Ruolin Liu, Evi S. Lianidou, Viktor A. Adalsteinsson, Gerassimos Mike Makrigiorgos
The paper introduces aMAPP, a PCR-based method to enrich methylated or unmethylated CpGs, enabling sensitive detection of DMRs in cancer samples with low DNA input.
Nucleic Acids Research · Jan 16, 2026Peer-reviewedMolecular Biology