Gerassimos Mike Makrigiorgos

MEDUSA improves sequencing accuracy by minimizing DNA duplex resynthesis during library preparation, achieving lower residual SNV frequency in genomic and cell-free DNA.

The paper introduces aMAPP, a PCR-based method to enrich methylated or unmethylated CpGs, enabling sensitive detection of DMRs in cancer samples with low DNA input.

Methyl-CODEC enables simultaneous methylation and duplex sequencing, improving mutation detection and distinguishing methylated Cs from mutations.

This study shows that aerosol delivery of Hesperetin-loaded nanoparticles and anti-CD40 antibody improves survival in a murine lung cancer model.

The paper identifies DNA strand resynthesis as a source of false mutations in sequencing and introduces Duplex-Repair to reduce this error, improving sequencing accuracy.

MAESTRO enables efficient and accurate tracking of thousands of low-frequency mutations with reduced sequencing, improving mutation testing in cancer and liquid biopsies.