Sally A. Amundson

This study evaluates how age and sex affect gene expression-based radiation biodosimetry in mice, finding that while accuracy varies, age and sex must be considered for effective dose prediction.

The paper tests hematopoietically humanized mice as a model for radiation gene expression biomarkers, finding they better replicate human gene responses than standard mice.

The paper develops a method to quantitatively reconstruct radiation dose from blood samples using transcriptomics, achieving predictions up to 6 Gy with RMSE of 1.74 Gy.