Pei-Chieh Tien

This study shows that MFSD12 is essential for mouse embryonic development by supplying reduced cysteine to lysosomes, and cysteamine treatment rescues Mfsd12 knockout mice.

DrugMap quantitatively analyzes cysteine ligandability across 416 cancer cell lines, revealing redox state, conformational changes, and mutations as drivers of variability, and identifies covalent inhibitors targeting NFκB1 and SOX10.