Author

S. Chakra Chennubhotla

University of PittsburghORCID 0000-0002-0024-1627Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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Alexander BraceiD· 1 shared Arvind RamanathaniD· 1 shared Heng MaiD· 1 shared K.J.F. SatchelliD· 1 shared Mónica Rosas‐LemusiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiophysics

Alexander BraceORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintApr 16, 2026

Mechanistic insights into the association and activation of the SARS-CoV-2 2'-O-Methyltransferase (NSP16)

Heng Ma, Alexander Brace, Mónica Rosas‐Lemus…·Arvind Ramanathan

This study uses molecular dynamics simulations and AI/ML to elucidate how nsp10 activates nsp16's methylation function by stabilizing its SAM pocket and enabling RNA binding.

DOI 10.64898/2026.04.15.718757

protein structuremechanistic / dynamical model

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