K.J.F. Satchell

This paper identifies and characterizes AdvA, a unique protein in Acinetobacter baumannii essential for cell division, revealing its structural and functional divergence from typical nucleotidyl cyclases.

The paper reports a cryo-EM structure of detergent-bound Vibrio cholerae MakA, revealing its conformational changes and role in pore assembly.

The paper determines six structural states of PilU, a retraction ATPase, revealing its homohexameric assembly and conformational flexibility, which may explain its weak ATPase activity and dependence on PilT.

This study uses molecular dynamics simulations and AI/ML to elucidate how nsp10 activates nsp16's methylation function by stabilizing its SAM pocket and enabling RNA binding.

The paper demonstrates that synthetic nanocarriers deliver RAS-degrading mRNA to pancreatic tumors, reducing RAS levels and tumor growth.

This study identifies biantennary N-glycans as receptors for MARTX toxins in Vibrio vulnificus, showing their role in pathogenesis and broad cell targeting.

The paper resolves the x-ray structure of SARS-CoV and SARS-CoV-2 SUD-N/M domains and shows they have rotational flexibility, with disulfide bonds absent in pangolin-SARS and related viruses.

The paper determines the crystal structures of SARS-CoV-2 Nsp10/16 complexes before and after methylation, revealing the mechanism of RNA capping and its role in viral evasion of host defenses.