Structures of pUG-fold RNA bound to DNMT1 reveal a mechanism for RNA-mediated epigenetic regulation
Jessica J. Song, Thomas R. Cech, Vignesh Kasinath
This study determines the cryo-EM structures of DNMT1 bound to pUG-fold RNA, revealing two RNA-binding modes and their role in inhibiting DNMT1 activity.
bioRxiv · Sep 3, 2026 · PreprintBiochemistry