Thomas R. Cech

This study shows RTEL1 ATPase activity is essential for both telomere strand synthesis and TERT regulation, with reduced TERT providing an adaptive survival mechanism in RTEL1-defective cells.

This study evaluates thiomorpholino antisense oligonucleotides (TMOs) as telomerase inhibitors, showing they reduce telomerase activity and limit cancer cell proliferation.

This study determines the cryo-EM structures of DNMT1 bound to pUG-fold RNA, revealing two RNA-binding modes and their role in inhibiting DNMT1 activity.

The paper examines the expression patterns and functional relationships of human vault RNA paralogs through knockout experiments in cell lines, suggesting potential functional connections but no clear biological roles.

The paper identifies six lncRNAs that regulate gene expression in trans in human iPSCs, revealing isoform-specific effects and a systemic response to doxycycline exposure.

This study shows that RNA sequence determines whether it inhibits PRC2 methyltransferase activity by dimerizing the complex or retains its activity by binding monomers.

The paper investigates the role of G-tract RNAs and the DHX36 helicase in stress granule formation, finding that G-tracts do not influence mRNA partitioning into stress granules, and DHX36 limits stress granule formation by unwinding G-quadruplexes.

The paper shows that telomerase inhibitors TMPyP4 and PDS also inhibit telomeric C-strand synthesis by stabilizing DNA structures and blocking CST-PP binding.

This study investigates the DNA and RNA binding kinetics of ERα and Sox2, revealing distinct multiphasic binding mechanisms with ER showing novel triphasic association behavior.

The paper evaluates the RNA-dependence of PRC2 chromatin binding in human pluripotent stem cells using optimized rChIP-seq and mutant analyses, supporting original findings.

The paper investigates how Polycomb-mediated genome architecture facilitates long-range H3K27 methylation spreading in ESCs and iPSCs, revealing RNA-dependent DNA looping and developmental gene roles in chromatin organization.