Vignesh Kasinath

This study determines cryo-EM structures of MeCP2 bound to nucleosomes and identifies how RTT mutations affect nucleosome interactions and chromatin targeting.

This study determines the cryo-EM structures of DNMT1 bound to pUG-fold RNA, revealing two RNA-binding modes and their role in inhibiting DNMT1 activity.

This study identifies EZH2 serine 21 phosphorylation as a mechanism that limits PRC2 activation and H3K27me3 propagation, affecting developmental processes in mesenchymal progenitor cells.

The paper evaluates sampling, loss functions, and masking strategies for vEM organelle segmentation, finding that these factors significantly impact performance, especially for rare classes.

This study determines the structure of human HIRA with a nucleosome, revealing its active role in a stepwise nucleosome assembly mechanism.

This study shows that RNA sequence determines whether it inhibits PRC2 methyltransferase activity by dimerizing the complex or retains its activity by binding monomers.

The paper designs a cyclic peptide that activates PRC2, leading to increased H3K27 trimethylation and improved stability in mice.

The paper reveals how H3K4me3 and H3K36me3 inhibit PRC2 activity by blocking its interaction with chromatin and allosteric activators, using cryo-EM.