Anuj Guruacharya

The paper designs AI-guided nanobodies targeting the VQIVYK motif of tau, showing strong binding to synthetic tau and Alzheimer's brain tissue.

Cirrina, an LLM-driven pharmacological reasoning agent, improves preclinical CNS drug evaluation by integrating mechanistic tools and providing better decision accuracy than deterministic pipelines.

This paper develops a Bayesian pharmacokinetic framework to improve uncertainty-aware first-in-human dose selection for monoclonal antibodies by incorporating allometric scaling and population-level variability.

This study applies VQE to a tau peptide fragment to compare quantum and classical methods in calculating electronic energies and highlights their complementary roles in peptide biophysics.

This paper introduces codonGPT, a generative language model for mRNA sequences, and a reinforcement learning framework for optimizing mRNA design under biological constraints.

The paper introduces Panama, an online tool and R library for simulating voltage-gated ion channel biophysics, addressing limitations in existing software.