Locus Suicide Recombination actively occurs on the functionally rearranged IgH allele in B-cells from inflamed human lymphoid tissues
Iman Dalloul, François Boyer, Zeinab Dalloul, Amandine Pignarre, Gersende Caron, Thierry Fest, Fabrice Chatonnet, Céline Delaloy, Anne Durandy, Robin Jeannet, Emilie Lereclus, Hend Boutouil, Jean‐Claude Aldigier, Sophie Péron, Sandrine Le Noir, , Michel Cogné
The paper shows that locus suicide recombination (LSR) occurs in human B-cells during activation, targeting the IgH locus and leading to cell death.
PLoS Genetics · Jun 14, 2019Peer-reviewedGenetics