Experimental change in personality: Overexpression of GDNF in the rat striatum converts the low exploratory phenotype into highly explorative
Jaanus Harro, Aet O’Leary, Marianna Norden, Kristi Liiver, Margus Kanarik, Arturo Garcia-Horsman, Sven Sakson, Pilleriin Kupper, Karita Laugus, Şirin Korulu, Indrek Teino, Tõnis Org, Ilmari Parkkinen, Tanel Kaart, Päivi Lindholm, , Märt Saarma
This study shows that overexpressing GDNF in the rat striatum changes a low exploratory behavior to highly explorative, suggesting GDNF's role in personality traits and potential therapeutic applications.
bioRxiv · Mar 16, 2025 · PreprintNeuroscience