Brandon K. Harvey

Title: Unilateral loss of tyrosine hydroxylase in adult midbrain dopaminergic neurons reveals reduction to neuregulin1 in rat model of acute dopaminergic dysfunction

This study creates a rat model of adult dopamine loss by knocking out tyrosine hydroxylase and identifies early transcriptional changes, including reduced neuregulin1, in dopaminergic neurons and surrounding cells.

Sigma-1 Receptor Promotes Glycolysis in Neuronal Systems by Suppressing GRIM19

This study shows that Sigma-1 receptor promotes glycolysis in neuronal systems by suppressing GRIM19, affecting NAD+/NADH metabolism and mitochondrial activity.

Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia

The paper describes the generation of a tamoxifen-inducible Cre driver rat for microglial transgene expression and validates its specificity and functionality.

SCOPE: Revealing Hidden Mechanisms in Phenotypic Screens Through Target and Pathway Enrichment

SCOPE identifies molecular mechanisms in phenotypic screens by linking compound data to pathways and targets, revealing calcium signaling and HRH1 as key in exodosis regulation.

Experimental change in personality: Overexpression of GDNF in the rat striatum converts the low exploratory phenotype into highly explorative

This study shows that overexpressing GDNF in the rat striatum changes a low exploratory behavior to highly explorative, suggesting GDNF's role in personality traits and potential therapeutic applications.

A Rapid Method for Producing Adeno-Associated Viral Vectors Suitable for Transducing Rodent Neurons in vitro and in vivo

This paper introduces a simplified AAV packaging protocol that produces sufficient virus for testing in rodent CNS without requiring large equipment.

Excitotoxic glutamate levels cause the secretion of resident endoplasmic reticulum proteins

The paper shows that glutamate receptor activation causes ER Ca2+ depletion, leading to secretion of ER resident proteins and disrupting proteostasis during excitotoxicity.

Effect of selective lesions of nucleus accumbens μ-opioid receptor-expressing cells on heroin self-administration in male and female rats: a study with novel Oprm1-Cre knock-in rats

This study introduces a CRISPR-based Oprm1-Cre knock-in rat to investigate the role of nucleus accumbens MOR-expressing cells in heroin self-administration, finding sex-specific effects on acquisition and effort.