Märt Saarma

This study characterizes the CDNF-BiP interaction structurally and functionally, revealing CDNF's role as an antagonist of BiP nucleotide exchange and its neuroprotective effects.

This study shows that overexpressing GDNF in the rat striatum changes a low exploratory behavior to highly explorative, suggesting GDNF's role in personality traits and potential therapeutic applications.

This paper demonstrates that a novel C-CDNF fragment can protect neurons in Parkinson's and ALS models through non-invasive peripheral delivery.

This study identifies CDNF's mechanism of action by showing it rescues human dopamine neurons through direct binding to UPR sensors PERK and IRE1α.

This study examines the effects of CHMA1004, a METTL3/METTL14 activator, on anxiety, depression, and striatal gene expression in rats, finding increased locomotor activity and anxiolytic-like effects.

The paper identifies small molecule activators of m6A mRNA methylation that protect and regenerate dopamine neurons in Parkinson's disease models.

This study develops small-molecule FTO inhibitors that enhance dopamine neuron survival and show BBB penetration, with greater potency than existing AlkBH5 inhibitors.

This study identifies a direct binding of antidepressants to TRKB receptors, revealing a mechanism linking molecular interactions to antidepressant effects.

This study shows CDNF reduces ER stress and improves motor neuron survival in multiple ALS models, independent of genetic cause.

The paper shows that BT13, a GDNF receptor agonist, supports dopamine neuron survival in vitro and protects their function in a Parkinson's disease rat model by crossing the blood-brain barrier.

This paper develops a deep convolutional neural network for automated astrocyte detection in microscopy images, achieving accuracy comparable to human experts and faster runtime than existing methods.