Two-variable nullcline analysis of ionic general equilibrium predicts calcium homeostasis in ventricular myocytes
David Conesa, Blas Echebarria, Angelina Peñaranda, Inma Rodríguez Cantalapiedra, Yohannes Shiferaw, Enrique Álvarez-Lacalle
The paper uses a two-variable nullcline analysis to predict calcium homeostasis in ventricular myocytes and explains why SERCA gene therapy may fail to improve contraction despite increasing SERCA expression.
PLoS Computational Biology · Jun 5, 2020Peer-reviewedSystems Biology