Author

Enrique Álvarez-Lacalle

Universitat Politècnica de CatalunyaORCID 0000-0001-6824-6857Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:mouse· 1

Frequent Co-Authors

Blas EchebarriaiD· 2 shared David ConesaiD· 2 shared Yohannes ShiferawiD· 2 shared Angelina PeñarandaiD· 1 shared Inma Rodríguez CantalapiedraiD· 1 shared Leif Hove‐MadseniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

Blas EchebarriaORCID

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2 papers

Recent·Most cited

Cell BiologyPLoS Computational BiologyPeer-reviewedOct 26, 2026

Calsequestrin localization at RyR2 clusters enables calcium wave propagation in ventricular myocytes

David Conesa, Blas Echebarria, Leif Hove‐Madsen…·Enrique Álvarez-Lacalle

The paper develops a 3D computational model of mouse ventricular myocytes to show that calsequestrin2 (CASQ2) co-localization with RyR2 clusters is essential for reliable calcium wave propagation.

DOI 10.1371/journal.pcbi.1014449

mousestatistical model

𝕏 PostBluesky

Systems BiologyPLoS Computational BiologyPeer-reviewedJun 5, 2020

Two-variable nullcline analysis of ionic general equilibrium predicts calcium homeostasis in ventricular myocytes

David Conesa, Blas Echebarria, Angelina Peñaranda…·Enrique Álvarez-Lacalle

The paper uses a two-variable nullcline analysis to predict calcium homeostasis in ventricular myocytes and explains why SERCA gene therapy may fail to improve contraction despite increasing SERCA expression.

7 citations

statistical model

𝕏 PostBluesky