Oncogenic signaling in the adult Drosophila prostate-like accessory gland leads to activation of a conserved pro-tumorigenic program, in the absence of proliferation.
S. Jaimian Church, Ajai J. Pulianmackal, Joseph A. Dixon, Luke V. Loftus, Sarah R. Amend, Kenneth J. Pienta, Frank Cameron Cackowski, Laura Buttitta
This study shows that oncogenic signaling in adult Drosophila accessory glands activates a pro-tumorigenic program without proliferation, leading to tissue hyperplasia and aneuploidy through endoreduplication.
Disease Models & Mechanisms · Apr 1, 2025Peer-reviewedDevelopmental Biology