Sarah R. Amend

This study shows cancer cells survive genotoxic chemotherapy by entering a drug-tolerant persister state involving mitotic bypass and endocycling, which can be targeted by inhibiting WEE1 or Myt1.

This study identifies genes linked to cancer risk variation across species, showing indirect effects on body size dominate cancer suppression, while direct effects increase tumour prevalence.

This paper introduces a microfluidic platform for multi-marker EV profiling from single-cell clones, revealing EV marker heterogeneity and EpCAM correlation with cell proliferation.

This study identifies metabolic shifts in drug-tolerant persister cells that support antioxidant metabolism, offering new targets to overcome therapy resistance.

This study shows that cancer cells surviving cisplatin chemotherapy increase OMA1 activity and mitochondrial fragmentation to resist oxidative stress.

The paper shows polyaneuploid prostate cancer cells under hypoxia exhibit enhanced motility and aerotaxis driven by HIF-1α and RhoA, enabling invasion and intravasation.

The paper shows chemoresistant cancer cells are vulnerable to ferroptosis due to iron dysregulation, despite varying ferroptosis sensitivity in untreated cells.

This study shows that oncogenic signaling in adult Drosophila accessory glands activates a pro-tumorigenic program without proliferation, leading to tissue hyperplasia and aneuploidy through endoreduplication.

This study uses single-cell proteomics and RNA-seq to analyze drug-resistant prostate cancer cells, identifying proteomic sub-clusters and gene expression changes linked to morphological and functional traits.

The paper shows that metastatic tumors exhibit more punctuational molecular evolution compared to primary tumors, indicating different evolutionary modes in cancer progression.

This study shows that polyaneuploid cancer cells (PACCs) are pro-metastatic in vivo, based on in vitro and in vivo experiments in mouse models.

The paper identifies polyploid cancer cells as markers of chemotherapy resistance and recurrence in prostate cancer, linking them to poorer survival outcomes.

The paper optimizes data-independent acquisition (DIA) mass spectrometry for single-cell proteomics, achieving reliable quantification of proteins and post-translational modifications at sub-nano-gram levels.