Tethering-mediated recruitment of pioneer factors by NuRD enables signal dependent gene activation and protects cell identity
Rita S. Monteiro, Annika Charlotte Sell, Kristina Bennet Emdal, Sarah L. Lundregan, Christina Maria Schuh, Silvia Raineri, François Dossin, Édith Heard, Jesper.V. Olsen, Joshua M. Brickman
The paper identifies NuRD's role in tethering pioneer factors like SOX2 to transcription sites, enhancing ERK-dependent gene activation and maintaining cell identity.
bioRxiv · Aug 11, 2026 · PreprintMolecular Biology