Author

François Dossin

European Molecular Biology LaboratoryORCID 0000-0002-4085-1446Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Édith HeardiD· 2 shared Amaury VaysseiD· 1 shared Andrew N.J. TuttiD· 1 shared Annika Charlotte SelliD· 1 shared Aurélien BoreiD· 1 shared Beatrice F. TaniD· 1 shared Benedetto Daniele GiaimoiD· 1 shared Christina Maria SchuhiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMolecular Biology

Édith HeardORCID

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3 papers

Recent·Most cited

The FANCM-RMI1/2 complex promotes genomic instability and PARP inhibitor sensitivity in BRCA2-deficicient cells.

François Dossin, Mikaël Attia, Fabricio Montero Zuniga, Daniel González‐Acosta, Rachel Brough, Fei Song, Dragomir B. Krastev, Maya Raghunandan, Stephen J. Pettitt, Aurélien Bore, Amaury Vaysse, Raphaël Margueron, Massimo Lopes, Andrew N.J. Tutt, Christopher J. Lord, Ludovic Deriano

This study identifies FANCM-RMI1/2 as a driver of PARP inhibitor sensitivity in BRCA2-deficient cells, revealing distinct adaptation mechanisms between BRCA1 and BRCA2 loss.

Molecular Cell · Oct 1, 2026Peer-reviewedCancer Biology

Tethering-mediated recruitment of pioneer factors by NuRD enables signal dependent gene activation and protects cell identity

Rita S. Monteiro, Annika Charlotte Sell, Kristina Bennet Emdal, Sarah L. Lundregan, Christina Maria Schuh, Silvia Raineri, François Dossin, Édith Heard, Jesper.V. Olsen, Joshua M. Brickman

The paper identifies NuRD's role in tethering pioneer factors like SOX2 to transcription sites, enhancing ERK-dependent gene activation and maintaining cell identity.

bioRxiv · Aug 11, 2026 · PreprintMolecular Biology

SPEN is Required for Xist Upregulation during Initiation of X Chromosome Inactivation

Teresa Robert-Finestra, Beatrice F. Tan, Hegias Mira-Bontenbal, Erika Timmers, Cristina Gontan, Sarra Merzouk, Benedetto Daniele Giaimo, François Dossin, Wilfred F. J. van IJcken, John W.M. Martens, Tilman Borggrefe, Édith Heard, Joost H. Gribnau

This study shows that SPEN is essential for Xist upregulation during X chromosome inactivation initiation in female mouse ESCs by silencing Tsix.

Nature Communications · Dec 1, 2021Peer-reviewedDevelopmental Biology