Cancer BiologybioRxivPreprint
MAPK signaling links BRD2 chromatin occupancy to PI3K/AKT inhibitor sensitivity
Josefina Mendez, Simone Bruno, Alexandra Indeglia…·Alex Toker
This study identifies BRD2 as a co-targetable vulnerability with PI3K/AKT inhibitors in breast cancer, showing that BRD2 phosphorylation is required for chromatin binding and that targeting BRD2 enhances drug efficacy.
DOI 10.64898/2026.09.21.753236