MAPK signaling links BRD2 chromatin occupancy to PI3K/AKT inhibitor sensitivity
Josefina Mendez, Simone Bruno, Alexandra Indeglia, Tashbib Khan, Isabella Ranieri, Jingchao Wang, Jenny M. Hogstrom, Alissandra L. Hillis, Jonah Lee, John G. Clohessy, Taru E. Muranen, Wenyi Wei, Franziska Michor A, Karen M. Cichowski, Alex Toker
This study identifies BRD2 as a co-targetable vulnerability with PI3K/AKT inhibitors in breast cancer, showing that BRD2 phosphorylation is required for chromatin binding and that targeting BRD2 enhances drug efficacy.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology