Author

Kazuki Nagata

Tokyo University of ScienceORCID 0000-0002-0100-4199Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Chiharu NishiyamaiD· 4 shared Kenta IshiiiD· 3 shared Naoto ItoiD· 3 shared Hiroto KoudaiD· 2 shared Kazumi KasakuraiD· 2 shared Weiting ZhaoiD· 2 shared Yuki YamazakiiD· 2 shared Ko OkumuraiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersImmunology

Chiharu NishiyamaORCID

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4 papers

Recent·Most cited

Short-chain fatty acids modulate the development and the cell surface molecule expression of dendritic cells by epigenetic regulation

Weiting Zhao, Kazuki Nagata, Risako Akiyama, Yuki Yamazaki, Hiroto Kouda, R. Miura, Kenta Ishii, Ryusei Tokita, Naoto Ito, Norimasa Yamasaki, Osamu Kaminuma, Chiharu Nishiyama

This study shows that butyrate, a short-chain fatty acid, modulates dendritic cell development and surface molecule expression through epigenetic mechanisms and transcription factors.

Allergology International · Jun 1, 2026Peer-reviewedImmunology

Role of the IRE1α-XBP1 axis in IgE-dependent activation of mast cells

Hiroto Kouda, Kazuki Nagata, Riu Saito, Chiharu Nishiyama

This study investigates the role of the IRE1α-XBP1 axis in IgE-dependent mast cell activation and finds it is critical for degranulation and cytokine release in allergic responses.

International Journal of Molecular Sciences · May 18, 2026Peer-reviewedImmunology

The role of GATA2 in the expression of the soluble decoy receptor ST2/IL1RL1 in human and mouse mast cells

Kazuki Nagata, Kazumi Kasakura, Kenta Ishii, Naoto Ito, Mutsuko Hara, Nobuhiro Nakano, Ko Okumura, Chiharu Nishiyama

This study identifies GATA2 as a key regulator of sST2 expression in mast cells through chromosomal conformational changes.

Allergology International · May 22, 2025Peer-reviewedImmunology

PU.1 and TGF-β signaling transactivate CD103 expression in mast cells and dendritic cells: Opposite roles of GATA2 in the expression of mucosal mast cell-specific genes

Kenta Ishii, Kazuki Nagata, Niya Yamashita, Yuki Yamazaki, Yuta Akimoto, Weiting Zhao, Mariko Inoue, Naoto Ito, Kazumi Kasakura, Chiharu Nishiyama

The paper investigates the transcriptional regulation of CD103 in mast cells and dendritic cells, showing that PU.1 transactivates CD103 expression while GATA2 represses it.

bioRxiv · Feb 10, 2025 · PreprintMolecular Biology