PU.1 and TGF-β signaling transactivate CD103 expression in mast cells and dendritic cells: Opposite roles of GATA2 in the expression of mucosal mast cell-specific genes
Kenta Ishii, Kazuki Nagata, Niya Yamashita, Yuki Yamazaki, Yuta Akimoto, Weiting Zhao, Mariko Inoue, Naoto Ito, Kazumi Kasakura, Chiharu Nishiyama
The paper investigates the transcriptional regulation of CD103 in mast cells and dendritic cells, showing that PU.1 transactivates CD103 expression while GATA2 represses it.
bioRxiv · Feb 10, 2025 · PreprintMolecular Biology