The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues
Bingkuan Zhu, Kevin Fung, Hailey Huiyi Feng, Julia A. Beatty, Fraser Ian Hill, Anne C. N. Tse, Christopher J. Brackman, Thomas H. C. Sit, Agnès Poujade, Nicolas Gaide, Mariette Ducatez, Gilles Foucras, Malik J. S. Peiris, Shih-Chieh Ti, John Malcolm Nicholls, Hui‐Ling Yen
This study compares the attachment patterns of H5N1 HPAI HA proteins from clade 1 and 2.3.4.4b to avian and mammalian tissues, finding comparable binding despite antigenic divergence.
Journal of Virology · Sep 23, 2025Peer-reviewedMicrobiology