Shih-Chieh Ti

Coupling of tubulin acetylation to microtubule stabilization through molecular mimicry

This study identifies MTCL1 as a factor linking microtubule stabilization and acetylation, showing its role in neuronal function through molecular mimicry.

Phosphatidylinositol 3-phosphate promotes 53BP1 condensate-like assembly at DNA double-strand breaks

This study identifies PI(3)P binding to the 53BP1 tBRCT domain as essential for promoting 53BP1 condensate-like assembly at DNA double-strand breaks.

The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues

This study compares the attachment patterns of H5N1 HPAI HA proteins from clade 1 and 2.3.4.4b to avian and mammalian tissues, finding comparable binding despite antigenic divergence.

A cytoskeletal scaffold promotes motile cilia assembly by regulating transition-zone integrity

This study identifies KIF27 as a key regulator of motile cilia assembly by maintaining transition-zone integrity, revealing its role in ciliary structure and function across species.

TUBB4B variants specifically impact ciliary function, causing a ciliopathic spectrum

The paper identifies TUBB4B mutations causing distinct ciliopathic diseases by affecting microtubule dynamics and cilia formation in humans and mice.