Author

Sophie A. Fleck

Indiana University BloomingtonORCID 0000-0002-0126-1160Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Lesley N. WeaveriD· 2 shared Anna B. Zike· 1 shared Eleanor B. Goldstone· 1 shared Emily D. DeWitt· 1 shared M. Abel· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersPhysiology

Lesley N. WeaverORCID

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2 papers

Recent·Most cited

PhysiologyG3 Genes Genomes GeneticsPeer-reviewedJul 21, 2026

RNA Sequencing in Adult Drosophila Females Identifies Estrogen-Related Receptor-Dependent Transcriptional Changes in Metabolism, DNA Replication, and Translation

Sophie A. Fleck, Eleanor B. Goldstone, Lesley N. Weaver

This study uses RNA sequencing to identify ERR-dependent transcriptional changes in adult Drosophila females, revealing sex-specific effects on metabolism, DNA replication, and translation.

DOI 10.1093/g3journal/jkag186

Drosophilabulk RNA-seq

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Developmental BiologyDevelopmental BiologyPeer-reviewedMay 8, 2025

Estrogen-Related Receptor is Required in Adult Drosophila Females for Germline Stem Cell Maintenance

Anna B. Zike, M. Abel, Sophie A. Fleck…·Lesley N. Weaver

This study shows that ERR is required in adult Drosophila females for maintaining germline stem cells and promoting egg production, with cell-autonomous effects in the germline and not through adipocytes.

3 citations

Drosophilaexperimental assay

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