Myeloid-derived alveolar-like macrophages are a tractable model to understand the role of ontogeny in alveolar macrophage function ex vivo and in the lungs.
Reham A. Ammar, Andrew J. Olive
This paper develops a model of myeloid-derived alveolar-like macrophages (MAMs) to study their function compared to fetal liver-derived AMs, finding they are more inflammatory due to metabolic and epigenetic differences.
bioRxiv · May 21, 2026 · PreprintImmunology