METTL3 maintains epithelial homeostasis through m6A-dependent regulation of chromatin modifiers
Alexandra M. Maldonado López, Sijia Huang, Gina Pacella, Eun Kyung Ko, Hui Shen, Julian Stoute, Morgan Sinkfield, Amy Anderson, Stephen Marsh Prouty, Huabing Li, John T. Seykora, Kathy Fange Liu, Brian C. Capell
This study shows that METTL3 regulates chromatin modifiers via m6A-dependent mRNA degradation, affecting epithelial homeostasis and causing cutaneous and oral phenotypes.
bioRxiv · Dec 14, 2022 · PreprintMolecular Biology