Kathy Fange Liu

The paper identifies immunogenic endogenous dsRNAs by isolating MDA5 filaments and shows their suppression by ADAR1 and DDX3X.

The paper shows that rDNA breaks generate sense-antisense rRNA transcripts that activate immune signaling via MDA5 and RIG-I.

This study shows that impaired 5'ETS pre-rRNA cleavage disrupts nucleolar organization, leading to mislocalization of RNA and proteins, and broader nuclear architecture changes.

The paper examines rRNA transcription and abundance in normal and leukemic hematopoiesis, finding cell-type-specific variations and functional roles in myeloid differentiation.

This study identifies PHF6 and PHIP as a chromatin complex that represses AML stemness, showing their functional relationship and the impact of their mutations.

The paper shows DDX3X and DDX3Y form RNA-protein clusters that enhance their enzymatic activity and may promote liquid-liquid phase separation under stress.

This study shows that specific DDX3X mutants form hollow condensates, impairing catalytic activity and interacting differently with WT DDX3X and DDX3Y, which may explain sex-specific disease biases.

This study shows that DIMT1's non-catalytic function is essential for AML proliferation and identifies a target region for therapeutic intervention.

This study shows that METTL3 regulates chromatin modifiers via m6A-dependent mRNA degradation, affecting epithelial homeostasis and causing cutaneous and oral phenotypes.