John T. Seykora

This paper identifies LNS8801, a pure enantiomer of G-1 that acts as a GPER agonist, showing cancer suppression in preclinical models and potential as a therapeutic with a predictive biomarker.

The paper identifies Meibomian gland stem cell populations and mechanisms of aging using mouse models and finds Hh signaling regulates stem cell proliferation, with decreased Hh and EGF signaling in aged glands.

This study shows that PV autoantibodies trigger ER stress, leading to desmosome disruption and cell adhesion loss, and suggests ER stress as a therapeutic target.

This study develops a method to sequence individual human DRG neuron somas, identifies 16 neuronal types, and reveals human-specific nociceptor types and potential drug targets.

This study shows that METTL3 regulates chromatin modifiers via m6A-dependent mRNA degradation, affecting epithelial homeostasis and causing cutaneous and oral phenotypes.