Molecular BiologyMolecular TherapyPeer-reviewed
An aptamer-mediated base editing platform for simultaneous knock-in and multiple gene knockout for allogeneic CAR-T cells generation
Immacolata Porreca, Robert A. Blassberg, Jennifer A. Harbottle…·John J. Lambourne
This paper introduces a base editing platform for simultaneous gene knockout and transgene integration in T cells, showing higher efficiency and reduced chromosomal translocations compared to CRISPR-Cas9.
16 citations