Author

Immacolata Porreca

Horizon Discovery (United Kingdom)ORCID 0000-0003-2008-0477Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:variant calling· 2 Research Focus:drug response / drug discovery· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Jesse StombaughiD· 2 shared John J. LambourneiD· 2 shared Olga MielczarekiD· 2 shared Robert A. BlassbergiD· 2 shared Alice A. TorresiD· 1 shared Anja van Brabant SmithiD· 1 shared Ben TayloriD· 1 shared Bronwyn C. Joubert· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersMolecular Biology

Jesse StombaughORCID

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2 papers

Recent·Most cited

Minimal activation of the p53 DNA damage response by a modular cytosine base editor enables effective multiplexed gene knockout in induced pluripotent stem cells

Robert A. Blassberg, Olga Mielczarek, Jesse Stombaugh, Hanneke Okkenhaug, Alice A. Torres, Paul Russell, John J. Lambourne, Immacolata Porreca

This paper demonstrates a cytosine base editor that enables efficient and durable multiplexed gene knockout in iPSCs with minimal p53 activation and reduced DNA damage.

bioRxiv · Jun 5, 2025 · PreprintMolecular Biology

An aptamer-mediated base editing platform for simultaneous knock-in and multiple gene knockout for allogeneic CAR-T cells generation

Immacolata Porreca, Robert A. Blassberg, Jennifer A. Harbottle, Bronwyn C. Joubert, Olga Mielczarek, Jesse Stombaugh, Kevin Hemphill, Jonathan Sumner, Deividas Pazeraitis, Julia Liz Touza, Margherita Francescatto, Mike A. Firth, Tommaso Selmi, Juan Carlos Collantes, Žaklina Strezoska, , John J. Lambourne

This paper introduces a base editing platform for simultaneous gene knockout and transgene integration in T cells, showing higher efficiency and reduced chromosomal translocations compared to CRISPR-Cas9.

Molecular Therapy · Jun 26, 2024Peer-reviewedMolecular Biology