Author

Jesse Stombaugh

Revvity (United States)ORCID 0000-0001-9631-0748Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:variant calling· 2 Research Focus:drug response / drug discovery· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Immacolata PorrecaiD· 2 shared John J. LambourneiD· 2 shared Olga MielczarekiD· 2 shared Robert A. BlassbergiD· 2 shared Alice A. TorresiD· 1 shared Anja van Brabant SmithiD· 1 shared Ben TayloriD· 1 shared Bronwyn C. Joubert· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersMolecular Biology

Immacolata PorrecaORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJun 5, 2025

Minimal activation of the p53 DNA damage response by a modular cytosine base editor enables effective multiplexed gene knockout in induced pluripotent stem cells

Robert A. Blassberg, Olga Mielczarek, Jesse Stombaugh…·Immacolata Porreca

This paper demonstrates a cytosine base editor that enables efficient and durable multiplexed gene knockout in iPSCs with minimal p53 activation and reduced DNA damage.

DOI 10.1101/2025.06.05.656583

humanwhole-genome sequencing

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Molecular BiologyMolecular TherapyPeer-reviewedJun 26, 2024

An aptamer-mediated base editing platform for simultaneous knock-in and multiple gene knockout for allogeneic CAR-T cells generation

Immacolata Porreca, Robert A. Blassberg, Jennifer A. Harbottle…·John J. Lambourne

This paper introduces a base editing platform for simultaneous gene knockout and transgene integration in T cells, showing higher efficiency and reduced chromosomal translocations compared to CRISPR-Cas9.

16 citations

humanexperimental assay

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