Integrated metabolomic and genomic insights into amino acid incorporation within the hybrid polyketide-alkaloid antibiotic TLN-05220
Jennifer L. Cordoza, Rachel A. Johnson, A.T. Whiteley, Calista A. Horta, Jayna C. Nicholas, Diana M. Owen, Laura Rodriguez-Velandia, Gordon T. Luu, Valentina Z. Petukhova, Jackson T. Calhoun, Laura M. Sanchez, Shaun M. K. McKinnie, Katharine R. Watts
This study identifies enzymes involved in amino acid incorporation into the antibiotic TLN-05220 using metabolomic and genomic analyses.
ACS Chemical Biology · Jan 30, 2026Peer-reviewedBiochemistry