Author

Sarah Kimmins

McGill UniversityORCID 0000-0002-0168-7233Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Assay:DNA methylation· 2 Organism:human· 2 Organism:mouse· 2 Assay:ChIP-seq· 1 Research Focus:deconvolution· 1

Frequent Co-Authors

Christine LafleuriD· 3 shared Romain LambrotiD· 3 shared Vanessa DumeauxiD· 3 shared Amanda J MacFarlaneiD· 2 shared Anne-Sophie PépiniD· 2 shared Donovan ChaniD· 2 shared Jacquetta M. TrasleriD· 2 shared Marie-Charlotte DumargneiD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersDevelopmental Biology

Christine LafleurORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Altered sperm DNA methylation in overweight men associates with transposable element regulation of paternal origins of risk in children

Mathieu Schulz, Xiaojian Shao, Romain Lambrot, Christine Lafleur, Donovan Chan, Marie-Charlotte Dumargne, Amanda J MacFarlane, Sergey I. Moskovtsev, Guillaume Bourque, Tomi Pastinen, Clifford Lawrence Librach, Hope Alberta Weiler, Jacquetta M. Trasler, Sarah Kimmins

The paper identifies altered sperm DNA methylation in overweight men linked to transposable element regulation and potential impacts on offspring neurodevelopmental risks.

bioRxiv · Sep 15, 2025 · PreprintDevelopmental Biology

Paternal obesity alters the sperm epigenome and is associated with changes in the placental transcriptome and cellular composition

Anne-Sophie Pépin, Patrycja A. Jazwiec, Vanessa Dumeaux, Deborah Magdalena Sloboda, Sarah Kimmins

Paternal obesity alters sperm epigenetic marks at placenta-related genes and is linked to changes in placental gene expression and trophoblast cell composition.

eLife · Nov 29, 2024Peer-reviewedDevelopmental Biology

Exposure of Greenlandic Inuit and South African VhaVenda men to the persistent DDT metabolite is associated with an altered sperm epigenome at regions implicated in paternal epigenetic transmission and developmental disease - a cross-sectional study

Ariane Lismer, Xiaojian Shao, Marie-Charlotte Dumargne, Christine Lafleur, Romain Lambrot, Donovan Chan, Gunnar Vase Toft, Jens Peter Bonde, Amanda J MacFarlane, Riana Bornman, Natalie Hildegard Aneck-Hahn, S. Patrick, Janice L. Bailey, Christiaan de Jager, Vanessa Dumeaux, , Sarah Kimmins

This study examines the association between p,p-DDE exposure and sperm epigenome alterations in Greenlandic Inuit and South African VhaVenda men, identifying potential impacts on future generations.

bioRxiv · Aug 15, 2022 · PreprintGenomics

Sperm Histone H3 Lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction

Anne-Sophie Pépin, Christine Lafleur, Romain Lambrot, Vanessa Dumeaux, Sarah Kimmins

This study investigates how paternal obesity alters sperm histone methylation and its impact on offspring metabolic health across generations.

Molecular Metabolism · Feb 17, 2022Peer-reviewedDevelopmental Biology