Amanda J MacFarlane

Altered sperm DNA methylation in overweight men associates with transposable element regulation of paternal origins of risk in children

The paper identifies altered sperm DNA methylation in overweight men linked to transposable element regulation and potential impacts on offspring neurodevelopmental risks.

Timing of standard chow exposure determines the variability of mouse phenotypic outcomes and gut microbiota profile

This study shows that lifetime exposure to different chow diets significantly affects mouse phenotypes and gut microbiota, while developmental exposure reduces variability.

Excess folic acid exposure increases uracil misincorporation into DNA in a tissue-specific manner in a mouse model of reduced methionine synthase expression

This study shows high folic acid intake increases uracil in DNA and γH2AX foci in colon tissue but not liver in mice with reduced methionine synthase expression.

Exposure of Greenlandic Inuit and South African VhaVenda men to the persistent DDT metabolite is associated with an altered sperm epigenome at regions implicated in paternal epigenetic transmission and developmental disease - a cross-sectional study

This study examines the association between p,p-DDE exposure and sperm epigenome alterations in Greenlandic Inuit and South African VhaVenda men, identifying potential impacts on future generations.

Mutagenicity of folic acid deficiency and supplementation is tissue-specific and results in distinct mutation profiles

This study examines how folic acid deficiency and supplementation affect mutation rates in bone marrow and colon, revealing tissue-specific mutagenic effects.