Deborah Magdalena Sloboda

Obesogenic diet alters decidual differentiation and cell-cell communication in the mouse uterus

This study uses single-cell RNA sequencing to show how an obesogenic diet affects decidual differentiation and cell-cell communication in the mouse uterus.

Maternal high-fat, high-sucrose diet-induced excess adiposity is linked to placental hypoxia and disruption of fetoplacental immune homeostasis in late gestation

This study shows that maternal high-fat, high-sucrose diet leads to placental hypoxia and immune disruption in late gestation without significant fetal growth issues.

Paternal obesity alters the sperm epigenome and is associated with changes in the placental transcriptome and cellular composition

Paternal obesity alters sperm epigenetic marks at placenta-related genes and is linked to changes in placental gene expression and trophoblast cell composition.

Maternal obesogenic diet disrupts mid-gestation decidual immune and vascular homeostasis without impairing spiral artery remodelling

Intestinal permeability and peripheral immune cell composition are altered by pregnancy and adiposity at mid- and late-gestation in the mouse

This study examines how pregnancy and adiposity affect intestinal structure, permeability, and immune cell composition in mice at mid- and late-gestation.

Maternal adaptations in mouse lactation are vulnerable to diet-induced excess adiposity

This study examines how diet-induced excess adiposity in mice affects maternal physiological adaptations during lactation and postpartum health.

High-fat diet intake modulates maternal intestinal adaptations to pregnancy, and results in placental hypoxia and impaired fetal gut development

This study shows that high-fat diet during pregnancy alters maternal gut microbiota and barrier function, leading to placental hypoxia and fetal gut developmental issues.