Plasma Metabolite Associations with Incident Heart Failure with Reduced and Preserved Ejection Fraction
Bhavya Chebrolu, Priyam Choksi, Salvatore Carbone, Brittany Weber, Jessica Ann Lasky-Su, Elizabeth W. Karlson, Sheila M. Hegde, Leo Francis Buckley
The paper identifies plasma metabolites associated with incident heart failure with reduced (HFrEF) and preserved ejection fraction (HFpEF) using metabolomics and machine learning, finding higher glutamine levels increase risk while omega-3 fatty acids decrease it.
medRxiv · Jul 22, 2026 · PreprintGenetic & Genomic Medicine